Intratumoral Injectable Redox-Responsive Immune Niche Improves the Abscopal Effect in Radiotherapy.

Radiotherapy (XRT) is often utilized to improve the immune checkpoint blockade response in cancer management. Such combination treatment can enhance the abscopal effect, facilitating a prolonged and durable systemic response. However, despite intense research efforts, only a minority of patients respond to this approach, and novel strategies to increase the abscopal effect are urgently needed.

Reversible guest molecule encapsulation in the 3-D framework of a heteropolynuclear luminescent Zn4Eu2 cage complex.

Guest molecules of diethyl ether or methanol are reversibly encapsulated in cavities formed by the 3-dimensional supramolecular framework of heteropolynuclear, luminescent [Eu2Zn4L4(OAc)6(NO3)2(OH)2].2Et2O.