We demonstrate a new, to the best of our knowledge, range-scalable repeatered distributed acoustic sensing (DAS) solution sharing technology with existing long-haul subsea telecom networks capable of low noise and high spatial and temporal resolution. Single ended DAS interrogation through a 2227 km line comprising 39 repeatered fiber spans is demonstrated with a 10 m spatial resolution, a 1.78 kHz sampling rate, and a strain resolution of 35 pε/√Hz for the outermost span.
View Article and Find Full Text PDFWhole genome sequencing has transformed rare disease research; however, 50-80% of rare disease patients remain undiagnosed after such testing. Regular reanalysis can identify new diagnoses, especially in newly discovered disease-gene associations, but efficient tools are required to support clinical interpretation. Exomiser, a phenotype-driven variant prioritisation tool, fulfils this role; within the 100,000 Genomes Project (100kGP), diagnoses were identified after reanalysis in 463 (2%) of 24,015 unsolved patients after previous analysis for variants in known disease genes.
View Article and Find Full Text PDFBuccal delivery offers a promising alternative to e.g., oral or parenteral drug administrations by leveraging the mucosal membranes of the mouth to enhance drug absorption and enhance patient compliance.
View Article and Find Full Text PDFThe debate over legalizing medical assistance in dying (assisted dying) is ongoing, also in Nordic countries such as Sweden where assisted dying is illegal. A 2020 survey by the Swedish Medical Association highlighted varied perspectives, with 41% of physicians supporting and 34% opposing legalization. Professionals in palliative care were more negative toward it.
View Article and Find Full Text PDFInt J Technol Assess Health Care
November 2024
Objectives: This study investigates the impact of coronavirus disease 2019 (COVID-19) pandemic on HTAsiaLink members at the organizational level and provides recommendations for mitigating similar challenges in the future.
Methods: A survey was disseminated among HTAsiaLink members to assess the COVID-19 impact in three areas: (i) inputs, (ii) process, and (iii) outputs of the Health Technology Assessment organizations' (HTAOs) research operations and HTA process in general.
Results: Survey results showed that most HTAOs hired more staff and secured similar or higher funding levels during COVID-19.