Publications by authors named "J Steve Jacobsen"

We demonstrate a new, to the best of our knowledge, range-scalable repeatered distributed acoustic sensing (DAS) solution sharing technology with existing long-haul subsea telecom networks capable of low noise and high spatial and temporal resolution. Single ended DAS interrogation through a 2227 km line comprising 39 repeatered fiber spans is demonstrated with a 10 m spatial resolution, a 1.78 kHz sampling rate, and a strain resolution of 35 pε/√Hz for the outermost span.

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Whole genome sequencing has transformed rare disease research; however, 50-80% of rare disease patients remain undiagnosed after such testing. Regular reanalysis can identify new diagnoses, especially in newly discovered disease-gene associations, but efficient tools are required to support clinical interpretation. Exomiser, a phenotype-driven variant prioritisation tool, fulfils this role; within the 100,000 Genomes Project (100kGP), diagnoses were identified after reanalysis in 463 (2%) of 24,015 unsolved patients after previous analysis for variants in known disease genes.

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Buccal delivery offers a promising alternative to e.g., oral or parenteral drug administrations by leveraging the mucosal membranes of the mouth to enhance drug absorption and enhance patient compliance.

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The debate over legalizing medical assistance in dying (assisted dying) is ongoing, also in Nordic countries such as Sweden where assisted dying is illegal. A 2020 survey by the Swedish Medical Association highlighted varied perspectives, with 41% of physicians supporting and 34% opposing legalization. Professionals in palliative care were more negative toward it.

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Objectives: This study investigates the impact of coronavirus disease 2019 (COVID-19) pandemic on HTAsiaLink members at the organizational level and provides recommendations for mitigating similar challenges in the future.

Methods: A survey was disseminated among HTAsiaLink members to assess the COVID-19 impact in three areas: (i) inputs, (ii) process, and (iii) outputs of the Health Technology Assessment organizations' (HTAOs) research operations and HTA process in general.

Results: Survey results showed that most HTAOs hired more staff and secured similar or higher funding levels during COVID-19.

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