Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer.

Background: Co-occurring mutations in pairs of genes can pinpoint clinically relevant subgroups of cancer. Most colorectal cancers (CRCs) are microsatellite stable (MSS) and have few frequent mutations. Large patient cohorts and broad genomic coverage are needed for comprehensive co-mutation profiling.

The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.

Intercellular communication via gap junctions has a fundamental role in regulating cell growth and tissue homeostasis, and its dysregulation may be involved in cancer development and radio- and chemotherapy resistance. Connexin43 (Cx43) is the most ubiquitously expressed gap junction channel protein in human tissues. Emerging evidence indicates that dysregulation of the sorting of Cx43 to lysosomes is important in mediating the loss of Cx43-based gap junctions in cancer cells.

A critical view of the environmental condition of the Sognefjord.

The world oceans and seas are experiencing a dramatic decline in their health and viability. In the midst of this crisis, the Norwegian fjords represent under-studied and highly vulnerable ecosystems. Fjord chemistry and fjord ecosystems are poorly studied given the current focus on polar ice melting, fish stock reductions and oil disasters.

Recovery of cholinesterase activity in the earthworm Eisenia fetida Savigny following exposure to chlorpyrifos.

Organophosphorus (OP) insecticides inhibit cholinesterase activity, an essential process in the nervous system of most animals. Re-establishment of active enzymes is slow and depends on elimination of the insecticide from the body followed by two lengthy processes: Reactivation and/or biosynthesis of new enzymes. Earthworms (Eisenia fetida) were exposed to either clean or chlorpyrifos-containing (240 mg/kg) soil for 48 h.