Publications by authors named "J Steller"

Background: Fetal growth restriction (FGR) is a leading risk factor for stillbirth, yet the diagnosis of FGR confers considerable prognostic uncertainty, as most infants with FGR do not experience any morbidity. Our objective was to use data from a large, deeply phenotyped observational obstetric cohort to develop a probabilistic graphical model (PGM), a type of "explainable artificial intelligence (AI)", as a potential framework to better understand how interrelated variables contribute to perinatal morbidity risk in FGR.

Methods: Using data from 9,558 pregnancies delivered at ≥ 20 weeks with available outcome data, we derived and validated a PGM using randomly selected sub-cohorts of 80% (n = 7645) and 20% (n = 1,912), respectively, to discriminate cases of FGR resulting in composite perinatal morbidity from those that did not.

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The effects of galactic cosmic radiation on reproductive physiology remain largely unknown. We determined the impact of near-continuous low-dose-rate Californium-252 neutron irradiation (1 mGy/day) as a space-relevant analog on litter size and number of resorptions at embryonic day (E) 12.5 (n = 19 radiated dams, n = 20 controls) and litter size, number of resorptions, fetal growth, and placental signaling and transcriptome (RNA sequencing) at E18.

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Introduction: Predictive analytics may be a useful adjunct to identify training needs for exploration class medical officers onboard deep space vehicles.

Methods: This study used a preliminary version of NASA's newest medical predictive analytics tool, the Medical Extensible Database Probabilistic Risk Assessment Tool (MEDPRAT), to test the application of predictive analytics to exploration crew medical officer curriculum design for 5 distinct design reference mission (DRM) profiles. Partial and fully treated paradigms were explored.

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Article Synopsis
  • A study investigated the impact of maternal vitamin D levels during the first and second trimesters on fetal growth and pregnancy outcomes, revealing key findings regarding its importance during early pregnancy.
  • Results indicated that vitamin D insufficiency was common in the first trimester, with every 10 nmol/L increase in vitamin D correlating to better fetal length growth, but not influence weight or head size.
  • The study found a significant risk increase for preterm birth among mothers with very low vitamin D levels (<40 nmol/L), while second trimester levels showed no significant associations with growth patterns or outcomes.
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  • * In a case study, fetal distress—specifically bradycardia—was observed before any maternal symptoms, indicating that fetal complications can occur independently of the mother's health.
  • * The patient, a 34-year-old woman at full term, experienced seizures and cardiac arrest during an emergency cesarean delivery for fetal distress, leading to immediate interventions, stabilization, and recovery in the surgical intensive care unit.
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