Optimal Time for Nevus Sebaceous Excision and Predictors of Surgical Outcomes and Secondary Intralesional Neoplasms: The Mayo Clinic Experience Over 37 Years.

Background: Controversy exists around the optimal timing of resection of nevus sebaceous (NS). The authors aim to determine optimal timing of NS resection and identify predictors of surgical outcomes and secondary intralesional neoplasms.

Methods: Retrospective chart review of all patients with biopsy-proven NS diagnosis treated at the authors' institution between 1987 and 2024.

Imaging Yield, Surgical Findings, and Outcomes Following Surgical Excision of Lateral Brow Dermoid Cysts.

Purpose: To review cases of lateral brow dermoid cysts and gain insight into the utility of preoperative imaging, incidence of intraorbital extension, and recurrence rate.

Methods: This is a retrospective study of all patients who underwent excision of lateral brow dermoid cysts at the authors' academic center over a 37-year period.

Results: A total of 136 patients were included.

Raver1 links RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.

Unlabelled: Multiple cell death and inflammatory signaling pathways converge on two critical factors: receptor interacting serine/threonine kinase 1 (RIPK1) and caspase-8. Careful regulation of these molecules is critical to control apoptosis, pyroptosis and inflammation. Here we discovered a pivotal role of Raver1 as an essential regulator of pre-mRNA splicing, expression, and functionality, and the subsequent caspase-8-dependent inflammatory cell death.