Digital measures of respiratory and upper limb function in spinal muscular atrophy: design, feasibility, reliability, and preliminary validity of a smartphone sensor-based assessment suite.

Spinal muscular atrophy (SMA) is characterized by progressive muscle weakness and paralysis. Motor function is monitored in the clinical setting using assessments including the 32-item Motor Function Measure (MFM-32), but changes in disease severity between clinical visits may be missed. Digital health technologies may assist evaluation of disease severity by bridging gaps between clinical visits.

Moderation of Structural DNA Properties by Coupled Dinucleotide Contents in Eukaryotes.

Dinucleotides are known as determinants for various structural and physiochemical properties of DNA and for binding affinities of proteins to DNA. These properties (e.g.

Chemical synthesis and characterization of single-chain C-chloroparaffin materials with defined degrees of chlorination.

Technical chlorinated paraffins (CPs) are produced via radical chlorination of n-alkane feedstocks with different carbon chain-lengths (∼C-C). Short-chain CPs (SCCPs, C-C) are classified as persistent organic pollutants (POPs) under the Stockholm Convention. This regulation has induced a shift to use longer-chain CPs as substitutes.

A new synthesis approach for the generation of single chain CP mixtures composed of a few major compounds.

Chlorinated paraffins (CPs) are complex mixtures, which consist of thousands of individual compounds with no dominant representative. Consequently, knowledge on structure and environmental relevance of individual CP congeners is poor. Similarly to the synthesis of individual CPs, the generation of less complex CP mixtures that can be thoroughly analyzed may be used to overcome some drawbacks of the highly complex technical CP mixtures.

Chlorinated paraffins - A historical consideration including remarks on their complexity.

Chlorinated paraffins (CPs) are high production volume chemicals currently produced and used in higher quantities than any other medium-size polyhalogenated compound (class). In addition, the composition of industrial CP mixtures is highly complex and poorly understood. In this article, we searched in the literature for the beginning of the chlorination of alkanes and how this substance class developed from niche applications to unmatched quantities in various industrial applications.