Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections.

The precise role of neutrophil-derived reactive oxygen species (ROS) in combating bacterial uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study, we elucidate the antimicrobial significance of NADPH oxidase 2 (NOX2)-derived ROS, as opposed to mitochondrial ROS, in facilitating neutrophil-mediated eradication of uropathogenic Escherichia coli (UPEC), the primary causative agent of UTI. Furthermore, NOX2-derived ROS regulates NF-κB-mediated inflammatory responses in neutrophils against UPEC by inducing the release of nuclear factor erythroid 2-related factor 2 (Nrf2) from its inhibitor, Kelch-like ECH-associated protein 1 (Keap1).

Association of Gut Microbiota With Fatigue in Black Women With Polycystic Ovary Syndrome.

Background: Fatigue is a highly prevalent symptom for individuals with polycystic ovary syndrome (PCOS); however, characterization of fatigue and investigation into the gut microbiome-a pathway that may contribute to fatigue-remains inadequately explored in Black women with PCOS.

Objectives: The purpose of this cross-sectional study was to examine fatigue and its relationship to the gut microbiome in adult Black women with PCOS.

Methods: Adult Black women with a diagnosis of PCOS were recruited for this cross-sectional study.

Preventive Care Needs of the North Carolina Medicaid Expansion Population.

Introduction: Effective December 2023, North Carolina expanded Medicaid eligibility to cover individuals up to 138% of the Federal Poverty Level. The authors sought to understand the preventive care needs of the newly Medicaid-eligible population.

Methods: The authors conducted a repeat cross-sectional analysis using the 2016, 2018, 2020, and 2022 North Carolina Behavioral Risk Factor Surveillance Survey.

RANZCP Position Statement 46: A missed opportunity to provide sophisticated guidance on asylum seeker and refugee policy.

Objective: To stimulate discussion on how the RANZCP can contribute more constructively to the debate over Australia's immigration policies.

Conclusions: Updated in March 2024, RANZCP Position Statement 46, titled: 'The provision of mental health services for asylum seekers and refugees', continues the College's advocacy for a compassionate stance towards asylum seekers and refugees on the grounds of preventing or improving their mental health. College statements over the last decade have raised concerns about policies that are designed to deter boat arrivals; and recently, have endorsed the High Court's NZYQ decision to mandate community release of detained non-Australian citizens deemed to have failed 'the character test' under the .

C2-Linked Arabinose-Functionalized Polystyrene Microbeads Selectively Target .

Carbohydrates play pivotal roles in the first stages of microbial infections and can be exploited as decoys to hijack the interactions between bacteria and the host cell. Multivalent glycan probes mimicking the natural presentation of glycans in living cells have been successfully employed to study fundamental carbohydrate/protein interactions in microbial systems; however, most pathogenic glycan receptors exhibit a shared specificity for commonly found sugars present in both healthy and pathogenic cells, posing a challenge for target selectivity. In this study, we report the synthesis of a small library of d-arabinose multivalent probes, a sugar absent in human physiology, and their evaluation in a bacteria agglutination assay using cluster analysis.