Publications by authors named "J Southwood"

Unlabelled: WHAT IS KNOWN ON THE SUBJECT?: Psychiatric hospitals have input from a range of professionals, including Clinical Psychologists. Most evidence used to guide what Clinical Psychologists do is based on their work with individuals rather than staff teams. Some evidence shows working with staff teams is important, but most of this is based on interviews rather than measuring the impact using numbers and statistics.

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Article Synopsis
  • Laryngopharyngeal reflux (LPR) causes inflammation in the larynx and is linked to serious diseases like cancer, but effective treatments are currently lacking.
  • The study utilized RNA sequencing to analyze how pepsin, a harmful component of refluxate, affects human laryngeal epithelial cells, identifying gene expression changes that may serve as biomarkers or therapeutic targets for LPR.
  • Results showed that pepsin exposure activated cancer-related signaling pathways, thus highlighting potential mechanisms for how chronic reflux could lead to cancer development, and established a new cell line for further research on these pathways.
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Invasive fungal infections are a serious cause of morbidity and mortality in patients with hematologic malignancies. Conidiobolus species are molds within the order Entomophthorales and may disseminate to become rapidly fatal in immunocompromised individuals. This species of fungal infections are often multidrug resistant (MDR) and present unique therapeutic challenges.

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In the standard functional endoscopic sinus surgery (FESS) procedure, the amount of dissection is often determined by the extent of disease with the goal to preserve as much normal mucosa as possible while restoring ventilation and reestablishing mucociliary clearance. A subset of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP), however, may continue to have persistent mucosal inflammatory and aggressive polyp regrowth despite standard FESS and maximal pharmacology therapy, leading to recurrent and recalcitrant disease. Advanced endoscopic surgery techniques such as the modified endoscopic medial maxillectomy, endoscopic modified Lothrop procedure, otherwise known as a Draf 3 frontal sinusotomy, and nasalisation or radical ethmoidectomy are extensive surgical procedures to maximize disease clearance while providing sizeable drainage pathways for effective postoperative surveillance and topical delivery of medications.

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Objectives: The aim of this study was to present a rare case of a venous malformation that occupied the ethmoid and sphenoid sinuses. Prior to resection, it was believed to be a hemangioma.

Methods: This study includes a case report and review of the literature.

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