Publications by authors named "J Soto-Hernaez"
Background: Age-related macular degeneration (AMD) remains a primary cause of blindness, with neovascular AMD (nAMD) presenting particular treatment challenges. Despite anti-vascular endothelial growth factor (anti-VEGF) therapies, many patients exhibit a suboptimal response to the previously available anti-vascular endothelial growth factor (anti-VEGF) therapies. This study evaluates the efficacy and treatment interval extension of faricimab in this patient cohort.
View Article and Find Full Text PDFAims: Guidelines have recommended reporting coronary artery calcification (CAC) if present on chest CT imaging regardless of indication. This study assessed CAC prevalence, prognosis and the potential clinical impact of its reporting.
Methods: We performed a single-centre retrospective analysis (January-December 2015) of 1400 chest CTs (200 consecutive within each age group: <40, 40-49, 50-59, 60-69, 70-79, 80-89, ≥90).
Context: Primary hyperparathyroidism (PHPT) is associated with increased risk of morbidity and death, and vitamin D levels are a potentially confounding variable.
Objective: The aim of this study was to assess morbidity and mortality associated with primary hyperparathyroidism (PHPT).
Methods: In this population-based retrospective matched cohort study, data linkage of biochemistry, hospital admissions, prescribing, imaging, pathology, and deaths was used to identify patients across the region of Tayside, Scotland, who had PHPT from 1997 to 2019.
Article Synopsis
- The study aimed to correlate genome-wide association study (GWAS) findings with serum thyroid-stimulating hormone (TSH) levels and hypothyroidism diagnosis, while also exploring the relationship between TSH and bone fracture risk.
- A cross-sectional approach was utilized in a cohort of European Caucasian patients, analyzing electronic medical records and genetic data through regression models and Mendelian randomization to assess causality.
- Results showed that higher TSH levels linked to genetics were significantly associated with increased hypothyroidism risk and a reduced risk of bone fractures in men, highlighting the importance of integrating genomic data with medical records for health insights.