Publications by authors named "J Sonne"
Article Synopsis
- * Urban areas displayed increased generalization in species interactions, demonstrating greater overlap and a link between lower rainfall and more generalized interaction networks.
- * Urban environments also showed reduced functional trait diversity among hummingbirds and a higher presence of nonnative nectar plants, affecting both species composition and the interactions within these ecological communities.
Background: In placebo-controlled clinical trials, reboxetine, a selective noradrenaline reuptake inhibitor, increases urethral pressure and relieves stress urinary incontinence symptoms in women. Considering the close connection in neural regulation of the external urethral and anal sphincters, we hypothesized that reboxetine may also enhance anal sphincter pressure. Conversely, it is believed that selective serotonin reuptake inhibitors may contribute to fecal incontinence by reducing anal sphincter pressure.
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- The study aimed to evaluate the safety, pharmacokinetics (how the drug moves through the body), and pharmacodynamics (the effects of the drug) of M6495, a new medication, in healthy volunteers and osteoarthritis patients.
- Two randomized, placebo-controlled studies were conducted: one with healthy men and another with osteoarthritis patients, assessing various doses and administration methods of M6495 over a period of 106 days.
- Results showed that M6495 was well tolerated with minimal adverse effects and significantly reduced biomarkers associated with osteoarthritis, indicating its potential as a disease-modifying treatment.