[Skin side effects of non-steroidal anti-inflammatory analgesics and so-called minor analgesics. Report from the Berne Comprehensive Hospital Monitor].

9118 of 19,653 inpatients of two internal medicine divisions were treated with analgesics and nonsteroidal antiinflammatory drugs including minor analgesics (NSAID). In the first part of the study all generalized skin reactions (gsr) considered to be probably or definitely due to a drug were evaluated clinically. In 23 out of 91 patients with a drug induced skin reaction, this was judged to be mainly related to an NSAID drug rather than any other drug (= 0.

[Exanthema during frequent use of antibiotics and antibacterial drugs (penicillin, especially aminopenicillin, cephalosporin and cotrimoxazole) as well as allopurinol. Results of The Berne Comprehensive Hospital Drug Monitoring Program].

Of 19,653 patients hospitalized in the medical divisions of two teaching hospitals, 3980 were treated with an aminopenicillin, 808 with other penicillins, 427 with a cephalosporin, 2619 with cotrimoxazole and 846 with allopurinol. The first part of the study deals only with the incidence of exanthemas definitely or probably due to a specific drug on the basis of clinical considerations. The exanthema incidence is 8.

Fall in systolic blood pressure due to metamizol (dipyrone, noramidopyrine, novaminsulfone). Results from the Comprehensive Hospital Drug Monitoring Berne (CHDMB).

A fall in systolic blood pressure which was not accompanied by any other symptoms of anaphylactic shock was first observed in 1972 and 1973 by our team in four patients after they had received metamizol-containing drugs parenterally. Of the 17,407 patients monitored from 1974-1981, ten further cases exhibited a fall in systolic blood pressure within minutes up to six hours after intravenous administration of metamizol. In all of these cases, a causal relationship between drug administration (0.

[Significance of age, sex, kidney function, atopy and number of prescriptions for the occurrence of adverse drug reactions, studied by multivariate statistical methods. Results from the Comprehensive Hospital Drug Monitoring Berne (CHDMB)].

Unlabelled: The influence of five factors (age, sex, renal function, atopy and number of drugs) on the incidence of adverse drug reactions (ADRs) is analysed by multivariate statistical methods (loglinear models for contingency tables). The study is based on a total of 19,653 inpatients in the "Comprehensive Hospital Drug Monitoring Berne (CHDMB)".

Results: 1.

[Influencing factors related to narcotic consumption and leisure sports in juveniles].

This report presents some results of a survey of 2872 men and women of 17 to 18 years of age. A multivariate analysis shows a strong association of consumption of illegal drugs with that of tobacco and alcohol, as well as with absence of spare time sports activities (men) and excessive use of medicaments (women). The results favour a multifactorial model of prevention of drug abuse.