Publications by authors named "J Soeterboek"
Pattern separation allows us to form discrete representations of information in memory. Pattern separation can be measured in several domains including spatial and object-based discrimination. The brain area largely involved in this process is the dentate gyrus of the hippocampus, which has been shown to be particularly sensitive to the effects of sleep loss.
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- The study explores the relationship between air pollution and its impact on cognitive functioning and brain health, given the rise in dementia cases and a lack of cures.
- It involved 4,002 participants from The Maastricht Study, analyzing various brain integrity markers and cognitive abilities while considering their residential air pollution exposure.
- Results showed no significant links between air pollution and cognitive performance or most brain markers, but a curvilinear relationship was noted where both low and high exposures were related to reduced grey matter volume.
Background: Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy.
Methods: We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.