Multi-stakeholder perspectives into the experiences of siblings when a child is critically ill: A qualitative systematic review.

Objectives: A child's critical illness and admission to intensive care can have significant short- and long-term impacts for the parents and hospitalized child. While experiences of parents have been explored, the impact on siblings remains unclear. The aim was to systematically review and synthesize qualitative research exploring the experiences of siblings when a child is critically ill, from the perspectives of siblings and relevant key stakeholders.

Longitudinal trajectories of the Scleroderma Health Assessment Questionnaire (SHAQ) visual analogue scales: a retrospective cohort study.

Objective: Systemic sclerosis (SSc) is disabling. However, the different factors contributing to this disability and how these change over time have been little studied. Our aim was to examine the trajectories over time of the six visual analogue scales (VAS) of the scleroderma HAQ (SHAQ), associations of disease-related factors with these trajectories, and relationships with overall functional ability.

Species circumscription within the Rediviva neliana group (Hymenoptera: Melittidae), with the description of the new species Rediviva vogeli sp. nov. Melin & Colville.

Rediviva neliana Cockerell 1931 has been considered to be widely distributed along the southeastern and eastern Escarpment of South Africa and Lesotho, with high variation in foreleg length recorded across populations. A recent analysis of the allometric relationship between foreleg length and body size for the oil-collecting species of Rediviva revealed that R. neliana is a notable 'outlier', suggesting that it represented a group of species and not a single taxon.

Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions.

Background: Severe malaria is associated with impaired nitric oxide (NO) synthase (NOS)-dependent vasodilation, and reversal of this deficit improves survival in murine models. Malaria might have selected for genetic polymorphisms that increase endothelial NO signaling and now contribute to heterogeneity in vascular function among humans. One protein potentially selected for is alpha globin, which, in mouse models, interacts with endothelial NOS (eNOS) to negatively regulate NO signaling.