The Measurement of Spatiotemporal Parameters in Running at Different Velocities: A Comparison Between a GPS Unit and an Infrared Mat.

The accurate measurement of spatiotemporal parameters, such as step length and step frequency, is crucial for analyzing running and sprinting performance. Traditional methods like video analysis and force platforms are either time consuming or limited in scope, prompting the need for more efficient technologies. This study evaluates the effectiveness of a commercial Global Positioning System (GPS) unit integrated with an Inertial Measurement Unit (IMU) in capturing these parameters during sprints at varying velocities.

Novel benzenesulfonamide-aroylhydrazone conjugates as carbonic anhydrase inhibitors that induce MAPK/ERK-mediated cell cycle arrest and mitochondrial-associated apoptosis in MCF-7 breast cancer cells.

A series of novel 4-alkylthio-2-chloro-5-[(2-arylmethylidene)hydrazinecarbonyl]benzenesulfonamide derivatives 3-22 were synthesized and evaluated for their inhibitory activity against human carbonic anhydrase isozymes hCA I, hCA II, hCA IX, and hCA XII. These compounds showed varying degrees of activity against the studied isoenzymes. However, the importance of substituent choice in designing potent carbonic anhydrase inhibitors is highlighted by the strong inhibition profiles of compounds 3 and 10 against hCA IX and the low average K values for compounds 9 and 10 (134 nM and 77 nM, respectively).

Effect of Advanced Footwear Technology Spikes on Sprint Acceleration: A Multiple N-of-1 Trial.

Background: In contrast with Advanced Footwear Technology-AFT running shoes for long-distance, little is known about AFT sprint spikes on performance and acceleration parameters. However, their use has become widespread since the Tokyo 2020 Olympics, and knowledge of their effects would seem to be an essential starting point before any clinical or socio-economic considerations.

Objectives: Our objectives were to determine intra- and inter-subject sprinting performance modifications with Nike AFT spikes (NAS) compared to standard spiked-shoes (SS).

Are the ground reaction forces altered by the curve and with the increasing sprinting velocity?

In 200- and 400-m races, 58% of the total distance to cover is in the curve. In the curve, the sprinting performance is decreased in comparison to the straight. However, the reasons for this decreased performance is not well understood.

New Chalcone Derivatives Containing 2,4-Dichlorobenzenesulfonamide Moiety with Anticancer and Antioxidant Properties.

Chalcones and their derivatives, both natural and synthetic, exhibit diverse biological activities. In this study, we focused on designing and synthesizing ()-2,4-dichloro--(4-cinnamoylphenyl)-5-methylbenzenesulfonamides - with the following two pharmacophore groups: 2,4-dichlorobenzenesulfonamide and chalcone. The obtained compounds displayed notable anticancer effects on various human cancer cells, such as cervical HeLa, acute promyelocytic leukemia HL-60, and gastric adenocarcinoma AGS, when assessed with the MTT test.