Cardiorespiratory Fitness After Open Repair for Acute Type A Aortic Dissection - A Prospective Study.

Cardiorespiratory fitness (as measured by peak oxygen consumption [VO]) is an independent predictor of cardiovascular disease and all-cause mortality. Limited data exist on VO following repair for an acute type A aortic dissection (ATAAD) or proximal thoracic aortic aneurysm (pTAA). This study prospectively evaluated VO, functional capacity, and health-related quality of life (HR-QOL) following open repair.

Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice.

Obesity is a major risk factor driving the global type II diabetes pandemic. However, the molecular factors linking obesity to disease remain to be elucidated. Gender differences are apparent in humans and are also observed in murine models.

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity.

Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a key downstream effector of mTOR complex 1 (mTORC1) that represses cap-dependent mRNA translation initiation by sequestering the translation initiation factor eIF4E. Reduced mTORC1 signaling is associated with life span extension and improved metabolic homeostasis, yet the downstream targets that mediate these benefits are unclear. Here, we demonstrated that enhanced 4E-BP1 activity in mouse skeletal muscle protects against age- and diet-induced insulin resistance and metabolic rate decline.

Comparative analysis of antioxidant activities of fourteen mentha essential oils and their components.

The essential oils of 14 species and hybrids, respectively, of the genus Mentha were examined for their antioxidant capacity in the ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)) assay and in a lipid-peroxidation (LPO) assay. The ABTS(.+) -scavenging capacity of pure essential-oil components and mixtures of them was also tested.