Publications by authors named "J Simon Arthur"
Background: Prolonged cold storage (CS) of kidneys results in poor long-term outcomes after transplantation (Tx). We reported previously that CS of rat kidneys for 18 h before transplant impaired proteasome function, disrupted protein homeostasis, and reduced graft function. The goal of the present study was to identify the renal proteins, including phosphoproteins, that are dysregulated by this CS injury.
View Article and Find Full Text PDFInflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, especially adherent-invasive Escherichia coli (AIEC). We previously demonstrated that AIEC producing the metallophore yersiniabactin (Ybt) promotes intestinal fibrosis in an IBD mouse model.
View Article and Find Full Text PDFArticle Synopsis
- * A scoping review conducted in Ghana analyzed 248 studies, finding that the majority of research focuses on sexual and reproductive health, but there is a lack of longitudinal studies and randomized control trials for more reliable data.
- * The review highlights the need for a broader range of youth-focused health interventions and research to address the diverse challenges faced by adolescents in Ghana, promoting their well-being as they transition into adulthood.
Article Synopsis
- Lassa fever (LF) is a viral hemorrhagic illness that is increasing in reported cases in Nigeria and is also endemic in West African countries.
- The study analyzed LF epidemiology data from Nigeria’s Centre for Disease Control and examined the genetic sequences of the virus to understand its evolution and outbreaks.
- To address the rising cases of LF, the study recommends enhancing diagnostic capabilities, raising public health awareness, implementing integrated surveillance, and supporting vaccine research in Africa.
Tuberculosis (TB) is characterized by immunopathology in the blood and monocytes have been shown to be highly sensitive to plasma environment changes in TB patients. Here, we investigated TB plasma effects on 'reference monocytes' using RNA sequencing to characterize a potential immunomodulatory role of monocytes in TB. Candidate pathways induced by plasma samples from TB patients (n=99) compared to healthy controls (n=62) were analyzed for changes in signal transduction, phenotype and secreted cytokines by flow cytometry.
View Article and Find Full Text PDF