Publications by authors named "J Silvestri"
Laboratory validation of a simplified DNA extraction protocol followed by a portable qPCR detection of M. tuberculosis DNA suitable for point of care settings.
PLoS One
December 2024
Tuberculosis, caused by Mycobacterium tuberculosis, is a treatable and curable disease, and yet remains one of the leading causes of death worldwide. Diagnosis is essential to reducing the number of cases and starting treatment, but costly tests and equipments that require complex infrastructure hamper their widespread use as a tool to contain the disease in vulnerable populations as well countries lacking resources. Therefore, it becomes necessary to develop new technological approaches to molecular methods as well as screening tests that can be rapidly conducted among people presenting to a health facility to differentiate those who should have further diagnostic evaluation for TB from those who should undergo further investigation for non-TB diagnoses.
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- Many care management programs for chronic lung disease fail to effectively reduce hospitalizations because they don't address the specific mechanisms causing them.
- The study examined the experiences of 22 patients with chronic lung disease who were hospitalized, focusing on common underlying issues that led to their acute exacerbations.
- Key findings included factors like difficulty managing symptoms at home, barriers to accessing healthcare, ongoing functional limitations, and mental health issues, which often existed long before hospitalization.
The COVID-19 pandemic produced stress for people around the world. The perception that tobacco can be a coping tool for stress relief suggests that the conditions during the COVID-19 pandemic can provide insight into the relationship between stress and tobacco use patterns, particularly among those most at risk for severe COVID-19 disease. The goal was to identify the impacts of the COVID-19 pandemic on tobacco use and preparedness for smoking cessation among individuals who smoke and are older and medically underserved.
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- Some people with dementia and their families prefer to stay at home as they feel it's the best care, but this isn't the same for everyone.
- A study with interviews found that many families avoid moving to care facilities until it's absolutely necessary, often because of fear or guilt.
- It's important for care programs to consider all the reasons families make decisions about where to live and to help them understand their options better.
Importance/study Objectives: The aim of this study was to determine whether the Social Vulnerability Index (SVI) is associated with the type of surgery for pelvic organ prolapse (POP) focusing on sacrocolpopexy (SCP) and uterosacral ligament suspension (USLS).
Study Design: This was a retrospective case-control study that included patients from 8 hospitals within a large academic health system in New York between January 1, 2018 and January 1, 2023. All patients 15-85 years of age with a preoperative diagnosis of POP who underwent a hysterectomy with an SCP or USLS were included.