Antifungal Action of Valencene and Nootkatone Compounds in Association with Fluconazole and Their Mechanism of Action Against Candida spp. and Pichia kudriavzevii Strains.

Candidemia is a public health challenge as it causes thousands of annual deaths and combating it has become difficult due to the development of resistance in Candida spp. Compounds derived from natural products may counter this resistance. Therefore, we evaluate the intrinsic and combined antifungal activity of valencene and nootkatone compounds and their possible mechanism of action against Candida spp.

The Influence of Alkaline Earth Metal Cations on the Performance of Platinum Electrodes during Brine Electrolysis.

The performance of platinum electrodes towards the hydrogen evolution reaction (HER) during pH neutral brine electrolysis was investigated in the presence of alkaline earth metal divalent cations, with focus on Mg2+ ions. This study aimed to understand the impact of these cations and/or their hydroxide deposits on electrode performance. Electrochemical measurements were conducted in electrolytes with varying Mg2+ concentrations (0 mM to 55 mM) in 1 M Na2SO4 solution.

Eight-Week Pilates or Whole-Body High-Intensity Interval Training Program Improves Spinal Range of Motion During the Gait Cycle in Sedentary Women: A Preliminary Study.

This study aimed to compare the effects of Pilates (PIL) and whole-body high-intensity interval training (WBHIIT) on the spinal curvature of sedentary women. After being invited, 26 sedentary women aged between 20 and 54 voluntarily agreed to participate in the study. The sample was obtained through convenience sampling, and the participants chose either PIL or WBHIIT, which resulted in 13 participants in each group.

Biofortified Sweet Potato Submitted to Different Domestic Cooking Processes: Impact on β-Carotene Retention and Antioxidant Capacity.

Sweet potato (Ipomoea batatas) is a source of fiber, carbohydrates, minerals and phytochemicals such as carotenoids and phenolic compounds. Biofortification with provitamin A carotenoid improves the nutritional properties of sweet potatoes and can contribute to reducing the deficiency of this micronutrient, but cooking may affect its composition. In this context, this study aimed to evaluate the effect of seven different domestic cooking processes (deep frying, air frying, steaming, boiling, pressure cooking, baking, and microwave cooking) on the color, phenolic compounds, antioxidant activity, and real retention of β-carotene in biofortified sweet potatoes.

rs17817449 Variant Increases the Risk of Severe Obesity in a Brazilian Cohort: A Case-Control Study.

Purpose: Obesity is a complex disease caused by a combination of genetic, environmental, and epigenetic factors, and is associated with an increased risk of chronic diseases. The leptin-melanocortin pathway integrates peripheral signals about the body's energy stores with a central neuronal circuit in the hypothalamus. This pathway has been extensively studied over the years, as genetic variations in genes related to it may play a crucial role in determining an individual's susceptibility to obesity.