Publications by authors named "J Shou"
Article Synopsis
- The study focuses on hypertensive intracerebral hemorrhage (HICH), a severe complication of high blood pressure, and aims to identify blood mRNA biomarkers associated with the condition.
- Researchers analyzed blood samples from 25 HICH patients and 22 healthy controls, identifying 3,163 differentially expressed genes and pinpointing 8 key mRNA candidates that may influence HICH development and complications.
- The findings revealed high complication rates among HICH patients, with factors such as age and specific gene expressions linked to issues like pulmonary infections and gastrointestinal bleeding, highlighting the clinical significance of these biomarkers.
Soil microbiota in intensive agriculture are threatened by pesticides, economic activities, and land-use changes. However, the interactions among these anthropogenic factors remain underexplored. By analyzing 2356 soil metagenomes from around the world, we developed a comprehensive soil health-microbial index that integrates microbial diversity, nutrient cycling potential, metabolic potential, primary productivity, and health risks to assess how the soil microbiota respond to anthropogenic factors.
View Article and Find Full Text PDFBuild-up of free cholesterol (FC) substantially contributes to the development and severity of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the specific mechanism by which FC induces liver injury in NAFLD and propose a novel therapeutic approach using dihydrotanshinone I (DhT). Rather than cholesterol ester (CE), we observed elevated levels of total cholesterol, FC, and alanine transaminase (ALT) in NAFLD patients and high-cholesterol diet-induced NAFLD mice compared to those in healthy controls.
View Article and Find Full Text PDFCisplatin-based chemotherapy is the recommended therapy for muscle-invasive bladder cancer (MIBC). However, the efficacy of MIBC for chemotherapy is only about 40%. Therefore, predictors of therapy response are urgently needed.
View Article and Find Full Text PDFArticle Synopsis
- Research focused on patients with metastatic clear-cell renal cell carcinoma (mccRCC) receiving immunotherapy and tyrosine kinase inhibitor (TKI) treatments to evaluate the role of serum immunoglobulin G (IgG) as a potential biomarker.
- Findings indicated that while baseline serum IgG levels did not significantly correlate with treatment response, an increase in serum IgG after 3 months of therapy was linked to a worse prognosis, including poorer progression-free survival (PFS) and overall survival (OS).
- The study concluded that elevated serum IgG levels after treatment serve as an independent risk factor for reduced patient outcomes, suggesting that monitoring IgG changes could help in evaluating treatment efficacy in mccRCC patients.