Publications by authors named "J Shiota"
Background: The distribution of body weight in patients with achalasia and after peroral endoscopic myotomy (POEM) has not been investigated. The role of body weight assessment after treatment remains unclear.
Methods: Using the multicenter achalasia cohort, the frequency of underweight (body mass index [BMI] < 18.
Article Synopsis
- Osteoarthritis (OA) is the most prevalent joint disease, involving cartilage breakdown and inflammation, with recent findings indicating that neutrophil extracellular vesicles (EVs) can help reduce inflammation and support cartilage health.
- Research involved isolating these EVs from neutrophils under different conditions to analyze their effects on chondrocytes (cartilage cells) and the underlying molecular mechanisms through mouse models of OA.
- The study revealed that EVs from neutrophils stimulated with TGF-β significantly inhibit harmful factors in chondrocytes, with the protein SFRP5 identified as a key player in these protective effects, suggesting potential avenues for OA treatment.
Given the potential fundamental function of osteal macrophages in bone pathophysiology, we study here their precise function in experimental osteoporosis. Gene profiling of osteal macrophages from ovariectomized mice demonstrated the upregulation of genes that were involved in oxidative stress, cell senescence, and apoptotic process. A single-cell RNA-Seq analysis revealed that osteal macrophages were heterogeneously clustered into 6 subsets that expressed proliferative, inflammatory, antiinflammatory, and efferocytosis gene signatures.
View Article and Find Full Text PDFEndoscopic submucosal dissection is a standard treatment for early esophageal squamous cell carcinoma. However, submucosal or lymphovascular invasion increases the risk of lymph node metastasis. Although F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters are associated with prognosis in patients with advanced esophageal squamous cell carcinoma, the utility of FDG PET/CT in diagnosing superficial esophageal carcinoma remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- * A modified scale (m-ES) was created to quantify symptoms like dysphagia, regurgitation, and chest pain, revealing that nearly 5% of patients still experience significant persistent symptoms affecting their QOL.
- * Results indicated that the m-ES correlates strongly with symptom severity and is more effective than the original Eckardt score in predicting persistent symptoms, with dysphagia and chest pain being the most common lingering issues.