Publications by authors named "J Shin Teh"
: Penile cancer is aggressive and rapidly progressive. Early recognition is paramount for overall survival. However, many men delay presentation due to a lack of awareness and social stigma.
View Article and Find Full Text PDFSite-specific π-clamp-mediated radiosynthesis of Ga and F PET radiopharmaceuticals.
Chem Commun (Camb)
January 2025
The π-clamp-mediated conjugation method, which enables site-specific modification of cysteine residues, is a promising strategy for developing well-defined radiolabelled biomolecules for positron emission tomography (PET) imaging. We have applied this method to site-specifically attach the macrocyclic chelators "NODA" and "NODAGA" to the somatostatin receptor 2-targeted peptide, octreotate. The resulting novel NODA-octreotate and NODAGA-octreotate compounds can be radiolabelled with either [F]AlF or [Ga]Ga respectively.
View Article and Find Full Text PDFBackground: There is considerable practice variation in labelling, diagnosis and treatment of adults with sterile bone inflammation. We developed a expert consensus recommendations on the disease definition, diagnosis and treatment of this rare condition.
Methods: Systematic literature review and Grading of Recommendations, Assessment, Development and Evaluations-based appraisal of evidence, two Delphi surveys and three digital and in-person consensus meetings with a multidisciplinary expert panel and patient representatives.
Article Synopsis
- Bulimia nervosa (BN) is a common psychiatric disorder that negatively impacts both the physical and mental health of those affected, with the role of fathers in this context being underexplored.* ! -
- A systematic review evaluated 2421 studies, narrowing them down to 29, to examine the psychosocial aspects of fathers of individuals with BN and their link to the children's outcomes.* ! -
- While no notable differences were identified in most psychological traits between fathers of BN sufferers and those in comparison groups, some father-specific factors were linked to increased risks of BN symptoms and poor treatment outcomes in their children, indicating the need for further research.* !
Article Synopsis
- Sleep architecture in people with depression, especially older adults, is not well-defined, prompting a study to compare sleep patterns between depressed and non-depressed individuals aged over 50.
- A systematic review identified 15 articles from over 2000, with data showing that depressed adults had significantly poorer sleep quality — less total sleep time, longer time to fall asleep, and more disruptions during the night compared to controls.
- Although older depressed adults had some distinct sleep characteristics, inconsistencies in findings and the removal of certain studies affected the overall results, indicating that differences in sleep architecture vary among different age groups and are not consistently observed.