Publications by authors named "J Shieh"
Article Synopsis
- Clinical shadowing allows preclinical medical students to observe doctors, helping them understand important clinical competencies through reflective writings.
- A thematic analysis was conducted on 155 reflective writings from students at National Taiwan University, revealing that patient care was the most frequently noted competency, followed by systems-based practice and medical knowledge.
- The majority of reflections were categorized as concrete experiences, indicating that students primarily learned through direct observation rather than through abstract thinking or reflection.
Background: Congenital myotonic dystrophy type 1 (DM1) is a rare congenital neuromuscular disorder associated with high morbidity and potential early mortality requiring lifelong symptomatic management. Prenatal presentations of DM1 have been associated with nonspecific ultrasound findings such as clubbed foot, polyhydramnios, ventriculomegaly, and decreased fetal movement, but many cases of DM1 have no ultrasound anomalies.
Methods: We sought to compare the clinical course and prenatal imaging findings in two cases of DM1 using retrospective chart review.
Mitochondria, vital organelles that generate ATP, determine cell fate. Dysfunctional and damaged mitochondria are fragmented and removed through mitophagy, a mitochondrial quality control mechanism. The FDA-approved drug IMQ, a synthetic agonist of Toll-like receptor 7, exhibits antitumor activity against various skin malignancies.
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- Duchenne muscular dystrophy (DMD) is a serious genetic disorder that results in muscle weakness and major health issues, and current imaging methods like quantitative ultrasound (QUS) assess muscle condition through fat and fibrosis metrics.
- The study introduces a new ultrasound technique called robust reference frequency method (RRFM) to improve imaging of muscle microstructures by measuring acoustic attenuation, which could serve as a key indicator for DMD.
- Results show that RRFM significantly enhances attenuation estimation accuracy—reducing bias by 50%—and demonstrates strong diagnostic performance in distinguishing between early and late stages of ambulatory function in DMD patients, outperforming traditional QUS methods.