Publications by authors named "J Sellers"
Purpose: Pigment epithelium-derived factor (PEDF) is a neurotrophic glycoprotein secreted by the retinal pigment epithelium (RPE) that supports retinal photoreceptor health. Deficits in PEDF are associated with increased inflammation and retinal degeneration in aging and diabetic retinopathy. We hypothesized that light-induced stress in C57BL/6J mice deficient in PEDF would lead to increased retinal neuronal and RPE defects, impaired expression of neurotrophic factor Insulin-like growth factor 1 (IGF-1), and overactivation of Galectin-3-mediated inflammatory signaling.
View Article and Find Full Text PDFPurpose: The aim of this study was to test whether oral administration of nicotinamide riboside (NR), the nicotinamide adenine dinucleotide (NAD+) precursors, protect retina ganglion cells (RGCs) from neurodegeneration in DBA/2J (D2) mice, which is a widely used mouse model of age-related inherited glaucoma.
Method: Oral NR or NAM administration (NR low dose: 1150mg/kg; NR high dose: 4200mg/kg; NAM low dose group: 500mg/kg; NAM high dose: 2000mg/kg of body weight per day) essentially started when D2 mice were 4 or 9 months old and continued up to 12 months old. Control cohort identically received food/water without NAM or NR.
The forced-response method: A new chronometric approach to measure conflict processing.
Behav Res Methods
December 2024
Despite long-standing concerns about the use of free reaction times (RTs) in cognitive psychology, they remain a prevalent measure of conflict resolution. This report presents the forced-response method as a fresh approach to examine speed-accuracy trade-off functions (SATs) in conflict tasks. The method involves fixing the overall response time, varying the onset of stimuli, and observing response expression.
View Article and Find Full Text PDFArticle Synopsis
- Non-muscle myosin II (NMII) plays a crucial role in biological processes, but current therapeutic options are limited due to non-selective inhibitors like blebbistatin that affect both NMII and cardiac myosin II (CMII).
- Researchers developed a series of selective NMII inhibitors, notably MT-228, which demonstrates high brain penetration and effectiveness in preclinical models for stimulant use disorder, a condition lacking FDA-approved treatments.
- The structure of MT-228 binding to myosin II reveals its 17-fold selectivity for NMII over CMII, providing insights for future drug development and potential applications in various medical fields, including cancer and nerve regeneration.
Researchers have long debated how humans select relevant objects amid physically salient distractions. An increasingly popular view holds that the key to avoiding distractions lies in suppressing the attentional priority of a salient distractor. However, the precise mechanisms of distractor suppression remain elusive.
View Article and Find Full Text PDF