Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach.

Background: Canine babesiosis is a tick-borne disease that is caused by the haemoprotozoan parasites of the genus Babesia. There are limited data on serum proteomics in dogs, and none of the effect of babesiosis on the serum proteome. The aim of this study was to identify the potential serum biomarkers of babesiosis using proteomic techniques in order to increase our understanding about disease pathogenesis.

Markers of coagulation activation, endothelial stimulation, and inflammation in dogs with babesiosis.

Background: Babesia infections in dogs can result in a wide range of clinical and laboratory presentations, including coagulopathy. Expression of intercellular adhesion molecule-1 (ICAM-1) and von Willebrand factor (vWF) in dogs with babesiosis is unknown.

Objectives: Whether inflammation in babesiosis triggers activation of ICAM-1 and the coagulation system.