Publications by authors named "J Seebacher"
Article Synopsis
- The study introduces qPISA, a new method for quantitatively analyzing protease specificity, particularly focusing on Dipeptidyl Peptidase Four (DPP4), which regulates blood glucose levels.
- Utilizing mass spectrometry, researchers quantified over 40,000 peptides, allowing for a deeper understanding of DPP4’s activity and revealing cooperative interactions within its active site.
- qPISA also distinguishes DPP4 from a similar enzyme in C. elegans and demonstrates potential applications in protein engineering, such as stabilizing GLP-1 for diabetes and obesity treatment.
Background: Previous studies found that in patients with profound hearing loss the NEO- personality factor Openness-to-experience is lowered.
Objective: Assuming that lowered Openness-to-experience may be due to limited access to sounds, we hypothesized that levels of Openness-to-experience would increase in these patients after cochlear implantation.
Material And Methods: Twenty adults (mean age: 61 years; active CI users) with bilateral profound hearing loss were assessed with the NEO-Five-Factor-Inventory before cochlear implantation (pre) and five years later (post).
Purpose: In this study, the objectification of the subjective perception of loudness was investigated using electroencephalography (EEG). In particular, the emergence of objective markers in the domain of the acoustic discomfort threshold was examined.
Methods: A cohort of 27 adults with normal hearing, aged between 18 and 30, participated in the study.
Measuring the electrically evoked stapedius reflex during the fitting of cochlear implants (CIs) provides a reliable estimation of maximum comfort levels, resulting in the programming of the CI with high hearing comfort and good speech understanding. Detection of the stapedius reflex and the required stimulation level on each implant channel is already being performed during surgery, whereby intraoperative stapedius reflexes are observed through the surgical microscope. Intraoperative stapedius reflex detection is both an indicator that the auditory nerve is responding to electrical stimulation up to the brainstem and a test for the ability to perform postoperative stapedius reflex measurements.
View Article and Find Full Text PDFPurpose: Cochlear implantation is a prevalent remedy for severe-to-profound hearing loss. Optimising outcomes and hearing preservation, and minimising insertion trauma, require precise electrode placement. Objective monitoring during the insertion process can provide valuable insights and enhance surgical precision.
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