Publications by authors named "J Sebastian Danobeitia"
Organ transplantation is characterized by a sequence of steps that involve operative trauma, organ preservation, and ischemia-reperfusion injury in the transplant recipient. During this process, the release of damage-associated molecular patterns (DAMPs) promotes the activation of innate immune cells via engagement of the toll-like receptor (TLR) system, the complement system, and coagulation cascade. Different classes of effector responses are then carried out by specialized populations of macrophages, dendritic cells, and T and B lymphocytes; these play a central role in the orchestration and regulation of the inflammatory response and modulation of the ensuing adaptive immune response to transplant allografts.
View Article and Find Full Text PDFTotal pancreatectomy with islet autotransplantation outcomes in patients with pancreatitis of genetic etiology: A single-center experience with a large cohort of patients.
J Gastrointest Surg
August 2024
Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for patients with chronic pancreatitis (CP) when other interventions are unsuccessful. CP has many etiologies including heredity. Metabolic and pain relief outcomes after TPIAT are presented among patients with a genetic CP etiology compared with those with a nongenetic etiology in a large cohort of patients who underwent this procedure at our center.
View Article and Find Full Text PDFArticle Synopsis
- Kidney transplant recipients (KTRs) are at high risk for severe COVID-19 outcomes, particularly hospitalization and mortality, with various risk factors identified such as older age, male sex, non-white race, and diabetes.* -
- A study involved 979 KTRs who contracted COVID-19 between April 2020 and April 2022, finding that 39% were hospitalized, and key risk factors for hospitalization and mortality were determined through multivariate analyses.* -
- Vaccination against SARS-CoV-2 significantly reduced risks of hospitalization and mortality in KTRs, highlighting the importance of vaccination in this vulnerable population.*
Background: Complement activation in kidney transplantation is implicated in the pathogenesis of delayed graft function (DGF). This study evaluated the therapeutic efficacy of high-dose recombinant human C1 esterase inhibitor (rhC1INH) to prevent DGF in a nonhuman primate model of kidney transplantation after brain death and prolonged cold ischemia.
Methods: Brain death donors underwent 20 h of conventional management.