Publications by authors named "J Sebag"
Tissue engineering of the vitreous body: recent progress and future trends.
Curr Opin Ophthalmol
February 2025
Purpose Of Review: In contrast to current clinically used tamponades including oils and gases, hydrogels offer a vitreous replacement that has the potential to present a niche for vitreous cells and elevate vitreous substitutes to the level of tissue engineering. This article, therefore, highlights and discusses recent hydrogel-based vitreous replacement strategies as well as the latest progress on vitreous cells, towards the development of a cellularized vitreous substitute.
Recent Findings: A variety of different crosslinked hydrogel systems have been recently investigated as preformed and in situ forming vitreous substitutes, based on biopolymers and/or synthetic polymers.
THERAPEUTIC REFRACTIVE VITRECTOMY (TRV) FOR THE MANAGEMENT OF VITREOUS FLOATERS AND OPACITIES (VFO) ASSESSED BY THE STANDARDIZED AND KINETIC ANATOMICAL AND FUNCTIONAL TESTING OF VITREOUS FLOATERS AND OPACITIES (SK VFO TEST).
Retina
December 2024
Purpose: Propose new terminology and evaluate the effectiveness of Therapeutic Refractive Vitrectomy (TRV) for selective removal of vitreous floaters and opacities (VFO) utilizing Standardized Kinetic Anatomical Functional Testing of VFO (SK VFO Test) and new ultra widefield (UWF) OCT imaging techniques.
Methods: Retrospective analysis. Twenty eyes underwent TRV for symptomatic VFO.
Article Synopsis
- The paper discusses the potential of carbon quantum dots (CQDs) as a dual-function tool for both inhibiting collagen fibers and using light to destroy them, which could provide a new treatment for eye floaters.
- The authors express concern over the safety and efficacy of CQDs in this application, urging further research to fully understand their effects.
- This study highlights the implications of using nanotechnology in medical treatments, particularly in addressing common visual issues like eye floaters.
As the medium for intravitreal drug delivery, the vitreous body can significantly influence drug delivery because of various possible liquefaction geometries. This work innovatively proposes a varying-porosity approach that is capable of solving the pressure and velocity fields in the heterogeneous vitreous with randomly-shaped liquefaction geometry, validated with a finite difference model. Doing so enables patient-specific treatment for intravitreal drug delivery and can significantly improve treatment efficacy.
View Article and Find Full Text PDFVision Degrading Myodesopsia From Posterior Vitreous Detachment Floaters.
J Vitreoretin Dis
July 2024