Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with a call to provide solutions to visualize tumor heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging to map tumor heterogeneity at the cellular and molecular scales with different levels of resolution. See related article by Bressan et al.
View Article and Find Full Text PDFThe landscape of tissue-based imaging modalities is constantly and rapidly evolving. While formalin-fixed, paraffin-embedded material is still useful for histological imaging, the fixation process irreversibly changes the molecular composition of the sample. Therefore, many imaging approaches require fresh-frozen material to get meaningful results.
View Article and Find Full Text PDFBackground: Health systems cannot effectively support nurse managers without understanding psychosocial effects of the COVID-19 pandemic.
Objective: The objective of this study was to describe the professional quality of life of frontline nursing management during the COVID-19 pandemic.
Methods: A cross-sectional online survey of 54 nurses in management positions at a large Midwest academic medical center during 2022 was conducted.