[Childhood acute lymphoid leukemia relapsing in adult age?].

A 30-years-old woman developed an acute lymphoblastic leukemia 16 years after a successfully treated childhood acute lymphoblastic leukemia. The developed second malignancy unexpectedly seemed identical to her previous malignant disease. That's why and because of the literature doesn't mention acute lymphoblastic leukemia as a second neoplasm after an acute lymphoblastic leukemia we considered the disease unusual late relaps of the original childhood malignancy.

Cytokines in the treatment of malignancies.

Cytokines are pleiotropic peptides produced by lymphoid cells that play important roles in cellular proliferation and multiplication. Diminished or enhanced production or constitutive secretion of cytokines contributes to the aetiology and pathogenesis of several diseases. They are soluble mediators eliciting specific responses of different target cells of paracrine, autocrine and cascade systems of the organism.

[Nephropathies associated with monoclonal gammopathies--a clinico-pathological study (author's transl)].

The subjects of this paper proves unequivocally that the excretion of lambda light chains must be considered a nephrotoxic process. It should be stressed, that although only a relatively small number of cases are known, this view is justified. According to our present knowledge, the process is irreversible and lethal.