Agential realism as an alternative philosophy of science perspective for quantitative psychology.

This paper introduces Karen Barad's philosophical framework of agential realism as an alternative philosophy of science perspective for quantitative psychology and measurement. Agential realism offers a rethinking of the research object, measurement process and outcome, causality, and the researcher's responsibility by proposing an ethico-epistem-ontological understanding of material-discursive practices that co-construct our world. The contemporary, canonical underlying philosophy of science perspective of quantitative psychology entails entity realism, a difference between ontic existence and epistemic approaches, complete causality, and determinism.

Thermoresponsive Brush Coatings for Cell Sheet Engineering with Low Protein Adsorption above the Polymers' Phase Transition Temperature.

Thermoresponsive polymer coatings on cell culture substrates enable noninvasive cell detachment and cell sheet fabrication for biomedical applications. Optimized coatings should support controlled culture and detachment of various cell types and allow chemical modifications, e.g.

Decisive role of mDia-family formins in cell cortex function of highly adherent cells.

Cortical formins, pivotal for the assembly of linear actin filaments beneath the membrane, exert only minor effects on unconfined cell migration of weakly and moderately adherent cells. However, their impact on migration and mechanostability of highly adherent cells remains poorly understood. Here, we demonstrate that loss of cortical actin filaments generated by the formins mDia1 and mDia3 drastically compromises cell migration and mechanics in highly adherent fibroblasts.

-containing spheres are a novel and predominant form of egress by the pathogen .

The egress of intracellular bacteria from host cells and cellular tissues is a critical process during the infection cycle. This process is essential for bacteria to spread inside the host and can influence the outcome of an infection. For the obligate intracellular Gram-negative zoonotic bacterium little is known about the mechanisms resulting in bacterial egress from the infected epithelium.