Publications by authors named "J Schoelmerich"
Background: In normal mucosa, intestinal lamina propria macrophages (IMACs) maintain tolerance against food antigens and the commensal bacterial flora. Several mechanisms have been identified that mediate tolerance. The ubiquitin-proteasome system (UPS) is a large multiprotein complex that degrades cellular proteins.
View Article and Find Full Text PDFUnlabelled: Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia. Most translocating bacteria belong to the common intestinal microbiota, suggesting a breakdown of intestinal barrier function. We hypothesized that diminished mucosal antimicrobial host defense could predispose to BT.
View Article and Find Full Text PDFBilberries have positive effects in acute and chronic diarrhea. Patients with inflammatory bowel disease (IBD) report on improved symptoms upon ingestion. Bilberries contain approximately 10% of anthocyanins (ACs), which have anti-oxidative, anti-carcinogenic, and anti-inflammatory properties.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates predictors of alcohol recidivism and the outcomes for liver transplantation (LT) patients with alcohol-toxic liver cirrhosis (ALC).
- Of the 226 patients who underwent LT, 53% had ALC, and the 5-year survival rate for these patients was significantly higher than those with other liver issues (78% vs. 64%).
- Key predictors for relapse include less than 3 months of alcohol abstinence prior to LT and a lack of acknowledgment of having an alcohol problem, both of which correlate to a higher likelihood of recidivism post-transplant.