Publications by authors named "J Schmit"
Amyloid fibrils are highly stable misfolded protein assemblies that play an important role in several neurodegenerative and systemic diseases. Although structural information of the amyloid state is now abundant, mechanistic details about the misfolding process remain elusive. Inspired by the Φ-value analysis of protein folding, we combined experiments and molecular simulations to resolve amino-acid contacts and determine the structure of the transition-state ensemble-the rate-limiting step-for fibril elongation of PI3K-SH3 amyloid fibrils.
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- * The study focused on JEN-101, a localized injection of interleukin-12 designed to boost immune response in dogs with advanced melanoma, evaluating its safety, effectiveness, and immune effects over several doses.
- * Results indicated that JEN-101 was well-tolerated with manageable side effects, and it showed promising biological responses, suggesting its potential for further research and relevance to human cancer treatment.
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- Compartment syndrome in the upper extremity is a critical condition typically resulting from specific injuries like fractures or burns.
- An unusual case involved an older woman who developed acute nontraumatic compartment syndrome due to acquired factor VIII deficiency, requiring a team of various medical specialists for diagnosis and treatment.
- Elevated partial thromboplastin time in a bleeding patient should indicate potential factor VIII deficiency, necessitating prompt evaluation and a coordinated treatment approach for better recovery.
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- This study analyzes how phase-separated compartments can influence enzymatic reactions, highlighting both the benefits of increased reactant concentration and the drawbacks of reduced mobility.
- While phase separation can enhance reactions under certain conditions, it can also hinder them if reactants become too immobilized, particularly in high-order or sequential reactions.
- An optimal balance of sticker affinity and spatial arrangement in the dense phase can maintain reactant mobility, suggesting that phase separation has significant potential to function as a reaction facilitator in cellular environments.
Zinc, a vital trace element, holds significant importance in numerous physiological processes within the body. It participates in over 300 enzymatic reactions, metabolic functions, regulation of gene expression, apoptosis and immune modulation, thereby demonstrating its essential role in maintaining overall health and well-being. While zinc deficiency is associated with significant health risks, an excess of this trace element can also lead to harmful effects.
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