Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy.

Background: Safe and effective antimalarials are required to protect pregnant women from the harmful effects of malaria.

Methods: Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy.

Results: In a traveler cohort of 236 pregnant women, spontaneous abortions were reported in 7.

Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa.

There is much confusion over which malaria chemoprophylaxis should be used in areas such as East Africa. We did two consecutive studies between 1985 and 1991 to assess the efficacy and side-effects of malaria chemoprophylaxis in short-term travellers to East Africa. All passengers returning from Kenya to Europe received an in-flight questionnaire and a second one three months later.