Evaluating the Safety and Effectiveness of Regional Upper GI Bleed Services Through an Outcome-Based Analysis at a Centre in the United Kingdom.

Background The aim of this study was to compare the clinical characteristics and clinical outcomes of patients who presented with acute upper gastrointestinal bleeding (AUGIB) among two groups of patients who were transferred from local and district hospitals for endoscopy and subsequent management versus direct admissions to the emergency department with AUGIB to the Sheffield University Hospital NHS Trust. Methods We included 259 patients who underwent upper GI endoscopy from April 2018 to March 2022, of whom 29 were transferred and 230 were direct admissions. The analysis focused on demographics, pathological findings, time to endoscopy, blood transfusions, and hospital stay.

Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism.

Detection of small molecule metabolites (SMM), particularly those involved in energy metabolism using MALDI-mass spectrometry imaging (MSI), is challenging due to factors including ion suppression from other analytes present (e.g., proteins and lipids).

Post-inflammatory Polyp Burden as a Prognostic Marker of Disease-outcome in Patients with Inflammatory Bowel Disease.

Background And Aims: Post-inflammatory polyps [PIPs] are considered as indicators of previous episodes of severe inflammation and mucosal ulceration. Inflammatory bowel disease [IBD], namely Crohn's disease [CD] and ulcerative colitis [UC], exhibit a perpetuating, relapsing and remitting pattern, and PIPs are a frequent sequela of chronicity. The aim of this study was to determine whether a high PIP burden is associated with a more severe disease course in patients with IBD.

Oesophagomediastinal fistula: a rare complication of tuberculosis.

We report a case of a woman from Thailand, living in Malta, who was diagnosed with concomitant tuberculosis (TB) and HIV with depleted CD4 count. Her case was further complicated by the formation of a fistula between the mediastinal lymph nodes and the oesophagus, an unusual finding but for which she had many risk factors. The diagnosis was suspected on CT scan of the thorax and confirmed via upper gastrointestinal endoscopy.

Identification of antibiotic resistance patterns in strains isolated from gastric biopsies using real-time PCR and genotypic analysis.

Background: is associated with dyspepsia, mucus-associated lymphoid tissue lymphoma, gastritis, and peptic ulcer disease. Treatment in Malta consists of triple therapy, which consists of a proton pump inhibitor and 2 of the antibiotics amoxicillin, clarithromycin, metronidazole and fluoroquinolones. We aimed to determine the resistance rates for clarithromycin and fluoroquinolones in patients with , and its incidence, in patients undergoing an esophagogastroduodenoscopy (EGD) using real-time polymerase chain reaction (RT-PCR).