Publications by authors named "J Scanzi"
Article Synopsis
- A nationwide study in France assessed the effectiveness of fecal microbiota transplantation (FMT) for treating Clostridioides difficile infection (CDI) across 17 centers from 2018 to 2022.
- The study found an overall FMT success rate of 84.3% with very few severe adverse events, and it identified factors linked to CDI recurrence such as severe chronic kidney disease and inadequate bowel cleansing.
- Key factors for improving FMT success included proper manufacturing of the transplant, thorough bowel prep, and individualized delivery methods based on patient needs.
Background & Aims: Because transmural healing (TH) could be the best therapeutic target in Crohn's disease (CD), we aimed to build and validate a score to assess TH and transmural response (TR), and to confirm their association with favorable CD outcomes.
Methods: DEVISE-CD project encompassed 2 retrospective cohorts (274 and 224 patients with CD for development and validation phase, retrospectively) and 1 multicenter prospective validation cohort (N = 46 patients). A step-by-step process was used to build the modified Clermont score (C-score).
Germline pathogenic variants in E-cadherin () confer high risk of developing lobular breast cancer and diffuse gastric cancer (DGC). The cumulative risk of DGC in carriers has been recently reassessed (from 40-83% by age 80 to 25-42%) and varies according to the presence and number of gastric cancers in the family. As there is no accurate estimate of the risk of gastric cancer in families without DGC, the International Gastric Cancer Linkage Consortium recommendation is not straightforward: prophylactic gastrectomy or endoscopic surveillance should be proposed for these families.
View Article and Find Full Text PDFThe potential benefits of Lactobacillus gasseri LA806 in IBS were previously identified in a comprehensive preclinical research program. The purpose of this multicenter study was to explore in real-life conditions changes in IBS symptoms and quality of life in patients receiving a 4-week supplementation with L. gasseri LA806.
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