Publications by authors named "J Sawada"
Identification of antimitotic sulfonamides inhibiting chromosome congression.
Biochem Pharmacol
December 2024
The discovery of new small-molecule inhibitors is essential to enhancing our understanding of biological events at the molecular level and driving advancements in drug discovery. Mitotic inhibitors have played a crucial role in development of anticancer drugs. Beyond traditional microtubule inhibitors, various inhibitors targeting specific mitotic factors have been developed.
View Article and Find Full Text PDFRecent discoveries of Homo floresiensis and H. luzonensis raise questions regarding how extreme body size reduction occurred in some extinct Homo species in insular environments. Previous investigations at Mata Menge, Flores Island, Indonesia, suggested that the early Middle Pleistocene ancestors of H.
View Article and Find Full Text PDFArticle Synopsis
- In 2022, Wenning et al. introduced the Movement Disorder Society Criteria for diagnosing Multiple System Atrophy (MSA) to improve diagnosis compared to previous methods.
- A study involved 68 patients registered with the Hokkaido Rare Disease Consortium, analyzing their conditions at three different times: initial evaluation, diagnosis, and final evaluation.
- Results showed an increase in the percentage of patients classified as clinically established MSA from 39.7% initially to 76.5% at the final evaluation, indicating clearer diagnostic criteria over time.
Objective We aimed to investigate the relationship between tortuosity of the extracranial internal carotid artery (ICA) or vertebral artery (VA) and vascular risk factors among residents of Asahikawa, northeast Japan. Methods We retrospectively surveyed participants of "brain dock" medical brain checkups, which involved magnetic resonance imaging and angiography. We measured the tortuosity of the ICA and VA, and evaluated vascular risk factors based on medical interviews, questionnaires, and medical records.
View Article and Find Full Text PDFBackground: Cerebrovascular diseases in cancer patients significantly aggravate their condition and prognosis; therefore, prompt and accurate diagnosis and treatment are important. The purpose of this study was to investigate patient demographics, laboratory data, brain magnetic resonance imaging (MRI) findings, and prognosis among patients with stroke and cancer, especially cancer-associated ischemic stroke (CAIS).
Methods: We performed a retrospective, single-center study.