Publications by authors named "J Santabarbara"
The relationship between depression, particularly major depression (MD), as a risk factor for Alzheimer's disease (AD) is well established; however, its precise role remains contested. Findings from the fourth wave of the ZARADEMP longitudinal study provide further insights into the association between MD and AD risk. : This study aimed to examine the association between MD and incident AD, controlling for established risk factors.
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- The study examined the link between mild behavioral impairment (MBI) and dementia risk in older adults, following 4,803 individuals over 4.5 years.
- It found that in cognitively normal participants, decreased motivation—an MBI domain—was linked to a significantly increased risk of all-cause dementia.
- The researchers suggest decreased motivation might indicate a higher dementia risk, but more studies are needed to explore the relationship between MBI and various types of dementia.
The definition of mental disorders has been traditionally a matter of discussion, and it has relevant implications in research and healthcare. Our aim was to explore the conceptualization medical students have of depression and to determine differences across academic years. The Maudsley Attitudes Questionnaire was adapted through a double translation, double back-translation and a preliminary validation, obtaining a Spanish edition.
View Article and Find Full Text PDFIntroduction: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.
Methods: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.
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- Most total disc replacements result in excessive mobility and can lead to chronic back pain due to their inability to mimic natural spinal movement.
- In a study involving cadaveric lumbosacral spines, researchers analyzed the movement after disc removal and subsequent prosthesis implantation, comparing flexion, extension, lateral bending, and rotation.
- The new ADDISC total disc replacement showed promise in mimicking natural disc kinematics but was unable to fully restore normal motion because the ligaments around the disc became destabilized during surgery, indicating a need for improved techniques in the future.