Glycemic variability is associated with reduced cardiac autonomic modulation in women with type 2 diabetes.

Objective: To investigate the sex differences in cardiac autonomic modulation in patients with newly diagnosed type 2 diabetes and to determine whether cardiac autonomic modulation is associated with glycemic variability.

Research Design And Methods: We investigated a cohort consisting of 48 men and 39 women with non-insulin-treated type 2 diabetes and a known duration of diabetes <5 years. All patients were equipped with a continuous glucose monitoring sensor for 3 days, and the mean amplitude of glycemic excursions (MAGE) was calculated to obtain individual glycemic variability.

Assessment of physical function in adults with Prader-Willi syndrome.

Purpose: To evaluate implementation of at test battery for assessing physical function in adults with Prader-Willi syndrome (PWS).

Method: Forty-three adults with PWS, 20 men and 23 women, mean age 29 +/- 9 years. Body mass index (BMI) and body composition were measured.

Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects.

Pituitary GH secretion is feedback regulated by circulating IGF-I. However, it remains to be determined whether the feedback control is mediated through circulating free or total IGF-I. To study this, we compared the temporal changes in circulating levels of GH vs.

No influence of prednisolone on IGFBP-3 proteolysis in healthy young men.

Aims: The impact of growth hormone (GH) and prednisolone on the GH/insulin-like growth factor (IGF) axis with special emphasis on IGF binding protein-3 (IGFBP-3) proteolysis was studied in 8 healthy adults in a double-blind cross-over study with four periods: (1) placebo; (2) s.c. GH 0.