Digital Twin-Assisted Lightpath Provisioning and Nonlinear Mitigation in C+L+S Multiband Optical Networks.

Multiband (MB) optical transmission targets increasing the capacity of operators' optical transport networks. However, nonlinear impairments (NLI) affect each optical channel in the C+L+S bands differently, and, therefore, the routing and spectrum assignment (RSA) problem needs to be complemented with fast and accurate tools to consider the quality of transmission (QoT) within the provisioning process. This paper proposes a digital twin-assisted approach for lightpath provisioning to provide a complete solution for the RSA problem that ensures the required QoT in MB optical networks.

Diabetes Remission After Bariatric Surgery: A 10-Year Follow-Up Study.

Introduction: Treatment of type 2 diabetes (T2DM) in patients with obesity can be challenging. Metabolic and bariatric surgery (MBS) has shown promising results in improving glycemic control and even achieving remission in T2DM patients with obesity. However, the durability of glycemic improvements in T2DM patients following MBS remains insufficiently studied.

Challenges in diagnosis and treatment of KCNJ11-MODY.

Summary: Maturity-onset diabetes of the young (MODY) is a subtype of monogenic diabetes and a rare type of diabetes, which accounts for 1-5% of cases and is often underdiagnosed. The importance of its diagnosis lies in the potential implications that it can have on disease management and offspring. We report a de novo KCNJ11-MODY case and the process of transition from insulin to sulfonylureas.

Neuritogenesis and protective effects activated by Angiotensin 1-7 in astrocytes-neuron interaction.

The renin angiotensin system (RAS) has been studied for its effects on various neurological disorders. The identification of functional receptors for Ang-(1-7) and Ang II peptides in astrocytes highlights the physiological modulation and the important role of these cells in the central nervous system. The present study aims to understand the role of RAS peptides, particularly Ang-(1-7) and Ang II, in the secretion of trophic factors by astrocytes and their effects on hippocampal neurons.