Photochemistry and Photophysics of Cholesta-5,7,9(11)-trien-3β-ol in Ethanol.

Cholesta-5,7,9(11)-trien-3β-ol (9,11-dehydroprovitamin D, CTL) is used as a fluorescent probe to track the presence and migration of cholesterol in vivo. We recently described the photochemistry and photophysics of CTL in degassed and air-saturated tetrahydrofuran (THF) solution, an aprotic solvent. The zwitterionic nature of the singlet excited state, CTL* is revealed in ethanol, a protic solvent.

α-Methylstilbene Isomers: Relationship of Structure to Photophysics and Photochemistry.

Significant differences in the photochemical and photophysical behavior of -α-methylstilbene and -stilbene have been attributed to structural changes caused by the steric requirements of the methyl group. We present here the X-ray structures of - and -α-methylstilbene (- and -MeSt). This is the first X-ray structure of a -stilbene.

Photochemistry and photophysics of cholesta-5,7,9(11)-trien-3β-ol: a fluorescent analogue of cholesterol.

Cholesta-5,7,9(11)-trien-3β-ol (9,11-dehydroprovitamin D, CTL) is used as a fluorescent probe to track the presence and migration of cholesterol in vivo. CTL is known to be photochemically active, but little consideration has been given to the formation efficiency and possible toxicity of its photoproducts. In degassed tetrahydrofuran (THF) solution, we isolated the photoproduct of CTL and of its 25-hydroxy derivative (HOCTL), and X-ray crystal structures were obtained for HOCTL and the photorearrangement product.

Acute Kidney Injury Presenting as Hepatorenal Syndrome in the Setting of Glecaprevir/Pibrentasvir Treatment for Hepatitis C.

A 65-year-old man with chronic hepatitis C virus and hepatocellular carcinoma, after surgical resection and chemotherapy, was started on a regimen of glecaprevir and pibrentasavir for treatment of his hepatitis C virus. Ten days later, he developed hepatotoxicity with subsequent progression to hepatorenal syndrome (HRS). On discontinuation of glecaprevir/pibrentasavir and initiation of HRS treatment, he had improvement in his renal and hepatic function.

Determination of the p Values of -Resveratrol, a Triphenolic Stilbene, by Singular Value Decomposition. Comparison with Theory.

Several independent determinations of the p values of -resveratrol in water have led to conflicting results. Singular value decomposition analysis of UV absorption spectra of -resveratrol (Resv) in N-outgased aqueous solutions buffered to pH values in the 7.0-13.