Publications by authors named "J Sallenave"
Silver nanoparticles (AgNPs) are a potential antiviral agent due to their ability to disrupt the viral particle or alter the virus metabolism inside the host cell. In vitro, AgNPs exhibit antiviral activity against the most common human respiratory viruses. However, their capacity to modulate immune responses during respiratory viral infections has yet to be explored.
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- The study emphasizes the under-researched role of myeloid cells, particularly monocytes and low-density neutrophils (LDNs), in COVID-19 disease and their impact on immune responses, especially against secondary bacterial infections.
- Findings reveal that COVID patients show increased LDNs that damage type II alveolar cells and that monocytes in COVID patients exhibit reduced responsiveness to bacterial infections, indicating impaired immune function in severe cases.
- Overall, the results suggest that COVID-19 alters the immune environment, leading to a biased T cell response and harmful functions of myeloid cells, which can exacerbate lung damage and hinder effective defenses against infections.
Epidemiological studies showed a positive association between exposure to PM and the severity of influenza virus infection. However, the mechanisms by which PM can disrupt antiviral defence are still unclear. From this perspective, the objective of this study was to evaluate the effects of PM on antiviral signalling in the respiratory epithelium using the bronchial Calu-3 cell line grown at the air-liquid interface.
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- Cystic Fibrosis (CF) is the most common inherited disease, affecting 1 in 4,500 babies, mainly caused by a problem with a protein called CFTR that regulates fluids in the body.
- In a study with young people who have mild CF, researchers looked at how their blood cells responded to different triggers compared to healthy people.
- They found that CF blood cells had higher levels of certain substances that can cause inflammation and showed signs of being both active and somewhat tolerant to triggers, which could affect their response to infections.