Search for Reactor-Produced Millicharged Particles with Skipper-CCDs at the CONNIE and Atucha-II Experiments.

Millicharged particles, proposed by various extensions of the standard model, can be created in pairs by high-energy photons within nuclear reactors and can interact electromagnetically with electrons in matter. Recently, the existence of a plasmon peak in the interaction cross section with silicon in the eV range was highlighted as a promising approach to enhance low-energy sensitivities. The CONNIE and Atucha-II reactor neutrino experiments utilize Skipper-CCD sensors, which enable the detection of interactions in the eV range.

Donor HLA-DQ genetic and functional divergence affect the control of BK polyoma virus infection after kidney transplantation.

BK polyomavirus (BKPyV) infection remains a major concern after kidney transplantation, increasing the risk of graft loss in the absence of specific antiviral agent now available. Here, we investigated the impact of HLA diversity on the control of posttransplant BKPyV replication. High HLA evolutionary divergence (HED) at the DQ locus in the donor was an independent predictor of BKPyV-free outcome.

Efficacy and safety of sipavibart for prevention of COVID-19 in individuals who are immunocompromised (SUPERNOVA): a randomised, controlled, double-blind, phase 3 trial.

Background: Sipavibart is an anti-spike monoclonal antibody that neutralises SARS-CoV-2 with exceptions, including Phe456Leu-containing variants (eg, KP.2* and KP.3*).

Understanding Nash epidemics.

Faced with a dangerous epidemic humans will spontaneously social distance to reduce their risk of infection at a socioeconomic cost. Compartmentalized epidemic models have been extended to include this endogenous decision making: Individuals choose their behavior to optimize a utility function, self-consistently giving rise to population behavior. Here, we study the properties of the resulting Nash equilibria, in which no member of the population can gain an advantage by unilaterally adopting different behavior.

Use of doravirine-based regimens in clinical practice in Europe: a real-life retrospective observational study.

Objectives: We evaluated antiviral effectiveness and safety of doravirine (DOR)-based regimens in people with HIV (PWH) in routine clinical practice.

Design: A retrospective, noninterventional study across 16 sites in five European countries [United Kingdom (UK), France, Spain, Belgium, Netherlands].

Methods: The study was conducted in both treatment-experienced and treatment-naive PWH who either switched to, or initiated DOR-containing antiretroviral therapy (ART).