Publications by authors named "J Sagawa"
Article Synopsis
- Protein-protein interactions (PPIs) are crucial for many biological functions, and understanding them is essential for studying how proteins work.
- The study proposes a straightforward method to assess PPI using mammalian cells, involving introduction of expression vectors, cell lysis, and protein isolation with an affinity gel.
- The researchers also suggest using affinity antibodies to confirm PPIs, highlighting the importance of maintaining protein integrity throughout the process for accurate results.
Adipose tissue is central to regulation of energy homeostasis. Adaptive thermogenesis, which relies on mitochondrial oxidative phosphorylation (Ox-Phos), dissipates energy to counteract obesity. On the other hand, chronic inflammation in adipose tissue is linked to type 2 diabetes and obesity.
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- * Long-term use of stimulants to maintain their function can have undesirable side effects, making PPARα a better target for preserving beige adipocytes.
- * Pemafibrate, a medication used for treating dyslipidemia, has been shown to enhance the thermogenic ability of these cells, reduce body weight gain, and improve glucose tolerance in obese mouse models.
Background: Mental health research is essential in the implementation of evidence-based interventions. This can be impeded by unavailability or limited access to local evidence in low- and middle-income countries (LMICs) such as Malawi.
Aim: The aim of this systematic mapping was to describe the availability, extent and distribution of mental health research conducted in Malawi.
Background: Postnatal care (PNC) service is a neglected yet an essential service that can reduce maternal, neonatal and infant morbidity and mortality rates in low and middle-income countries. In Malawi, maternal and infant mortality rates remain high despite numerous efforts by the government and its partners to improve maternal health service coverage across the country. This study examined the determinants of PNC utilization among mothers in Mangochi District, Malawi.
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