Publications by authors named "J Sabotic"
Glycosylation patterns represent an important signature of cancer cells that can be decoded by glycan-binding proteins, i.e., lectins.
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- Listeria monocytogenes can form tough biofilms in food processing areas, making it hard to eliminate despite existing control strategies.
- Research on fungal proteins showed that they effectively disrupt biofilm formation without directly killing the bacteria at higher temperatures.
- Fungal lectins specifically inhibited biofilm development at room temperature, suggesting potential use in preventing Listeria contamination on surfaces in food processing.
The pathogenic bacterium is a major food safety concern as it can form biofilms that increase its survival and infective potential. Biofilms consist of microbial cells and extracellular matrix (ECM), which is made of water and extracellular polymeric substances (EPS), which are critical for structural integrity and pathogenicity. The aim of this study was to optimize a protocol for the isolation of ECM.
View Article and Find Full Text PDFModulation of adhesion to biotic model surfaces by fungal lectins and protease inhibitors.
Front Cell Infect Microbiol
May 2024
Article Synopsis
- * The study tested different types of coordinated interactions between the bacterium, fungal lectins, and Caco-2 cells, finding that pre-incubation with lectins was most effective at reducing invasive bacterial cells.
- * These findings suggest that fungal lectins could be valuable in developing new treatments and preventive measures against such bacterial infections.
Certain soil insects, such as the root-damaging larvae of the maize pest (Coleoptera: Chrysomelidae), are increasingly difficult to control because of recent bans of some insecticides. An alternative and safer approach may be the development of biopesticides based on entomotoxic defense proteins of higher fungi. Many of these potentially interesting proteins are protease inhibitors, and some have been shown to adversely affect insects.
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