In silico oncology: exploiting clinical studies to clinically adapt and validate multiscale oncosimulators.

This paper presents a brief outline of the notion and the system of oncosimulator in conjunction with a high level description of the basics of its core multiscale model simulating clinical tumor response to treatment. The exemplary case of lung cancer preoperatively treated with a combination of chemotherapeutic agents is considered. The core oncosimulator model is based on a primarily top-down, discrete entity - discrete event multiscale simulation approach.

Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm.

The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens.

Image-guided reconstruction of the anterior cruciate ligament.

The replacement of the ruptured Anterior Cruciate Ligament (ACL) of the knee is a biomechanically difficult task. The correct placement of the graft, especially the isometry of the tibial and femoral insertion points, is critically to the success of the procedure. However, during arthroscopy, the planning of the insertion points and accurate execution of the plan is difficult.

4D rotational x-ray imaging of wrist joint dynamic motion.

Current methods for imaging joint motion are limited to either two-dimensional (2D) video fluoroscopy, or to animated motions from a series of static three-dimensional (3D) images. 3D movement patterns can be detected from biplane fluoroscopy images matched with computed tomography images. This involves several x-ray modalities and sophisticated 2D to 3D matching for the complex wrist joint.