Publications by authors named "J Saavedra-Lozano"
Impact of the COVID-19 Pandemic on Pediatric Bacterial Community-Acquired Pneumonia: A Multicenter Retrospective Study in Madrid (Spain).
David Aguilera-Alonso Juan Sánchez-Cañete Leyre Ventura McArdle Teresa Del Rosal Francisco José Sanz Santaeufemia Jesús Saavedra-Lozano
Pediatr Infect Dis J
October 2024
This study conducted in Madrid (Spain) between 2018 and 2023 shows a significant decrease in the pediatric bacterial community-acquired pneumonia cases during the COVID-19 pandemic, followed by a notable postpandemic increase surpassing prepandemic incidence. Streptococcus pneumoniae remains predominant, with an increasing prevalence of serotype 3, while Streptococcus pyogenes was the second most common pathogen.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate hearing outcomes at 24 months for infants with mild congenital cytomegalovirus (cCMV) infection, comparing those who received antiviral treatment to those who did not.
- Utilizing data from the European Registry of Children with cCMV, researchers included infants diagnosed with cCMV early in life, who had normal physical exams and mild imaging findings.
- Results showed that 34.7% of the 196 participants received antiviral treatment, but there was no significant difference in hearing loss prevalence between treated (4.6%) and untreated groups (6.3%) after two years.
Article Synopsis
- Klebsiella michiganensis is an emerging hospital pathogen that often carries antibiotic-resistance genes, including those for carbapenemases, prompting a redefined outbreak alert in a Spanish pediatric ward.
- The study analyzed 31 isolates of K. oxytoca with a focus on VIM-carbapenemase, using whole-genome sequencing to establish genetic relationships and identify resistance genes.
- The results confirmed an outbreak involving 18 cases across three wards, revealing complex interconnections and potential hidden reservoirs for the infection, underscoring the importance of genomic analysis in outbreak management.
Article Synopsis
- Immune-based TB diagnostic tests currently have low sensitivity in children and struggle to differentiate between latent TB infection (LTBI) and active TB disease.
- The study analyzed 17 biomarkers in plasma from children with confirmed TB, LTBI, and non-TB infections, finding significant biomarkers like IFN-γ and IL-2 that effectively predicted TB status.
- The IFN-γ/MCP-1 ratio emerged as the most promising combination for distinguishing between MTB-infected and non-infected children, suggesting a need for further research to improve pediatric TB diagnosis.
Diagnostic and therapeutic approach to spondylodiscitis in Spanish children through the RIOPed network: evaluation before and after the publication of the national consensus document.
Laura Martín Pedraz Esmeralda Núñez Cuadros María Belén Hernández Rosa María Alcobendas Rueda Jesús Saavedra-Lozano
An Pediatr (Engl Ed)
August 2024
Article Synopsis
- Pediatric spondylodiscitis (PSD) is a rare sickness in kids, and this study wanted to learn more about it since there are no specific guidelines for treating it.
- Researchers looked at two groups of patients from different times to see how well doctors followed the new treatment guidelines and to find out if any factors led to complications.
- They found that most kids improved without many problems, and doctors did a better job following the guidelines over time, especially in giving shorter antibiotic treatments.