Protein Misfolding and Aggregation of Pathological Igg Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications.

Neoplastic transformation of B cells of the post-germinative center can lead to oncohematological dyscrasias, which often results in an abnormal production of monoclonal immunoglobulin light chains. The non-physiological production of large amounts of IgG light chains leads to the formation of extracellular deposits called 'aggregomas' and rare conditions such as light chain crystal deposition disease. Kidney manifestations and heavy-chain deposition disease can also occur in plasma cell dyscrasias, emphasizing the role of IgG misfolding and aggregation.

Field determination of trace concentrations of hazardous metals in waters by portable EDXRF.

A new effective method has been developed for field determination of trace concentrations of cadmium, arsenic, zinc, copper, nickel, chromium, and lead in waters (e.g., surface and wastewater) using an energy dispersive X-ray fluorescence (EDXRF) analyzer.

Insights into the molecular basis of gastric mucosa as a first step for using Raman microscopy in paediatrics.

Recent advances in endoscopic technology have allowed detailed observation of the gastric mucosa, including Raman microscopy and spectroscopy. To explore the possibilities for future diagnostic use, we discuss the measurements and molecular markers found in this tissue. The Raman spectra of 16 samples of antral mucosa and 16 samples of corpus gastric mucosa obtained from healthy donors were analysed.

Stilbenes in and .

Stilbenes in the roots of and were studied. Root samples were extracted with 100% methanol and analyzed by HPLC and LC-MS. In this way, -resveratrol dimers (/ 455 Da [M + H]), trimers (/ 681 Da [M + H]) and tetramers (/ 907 Da [M + H]) were identified in the extracts.