Publications by authors named "J STERNE"
Harmonization of alcohol use data and mortality across a multi-national HIV cohort collaboration.
Alcohol Clin Exp Res (Hoboken)
January 2025
Background: Alcohol use is measured in diverse ways across settings. Harmonization of measures is necessary to assess effects of alcohol use in multi-cohort collaborations, such as studies of people with HIV (PWH).
Methods: Data were combined from 14 HIV cohort studies (nine European, five North American) participating in the Antiretroviral Therapy Cohort Collaboration.
Anticoagulation Among Patients Hospitalized for COVID-19 : A Systematic Review and Prospective Meta-analysis.
Ann Intern Med
December 2024
Background: Reported results of clinical trials assessing higher-dose anticoagulation in patients hospitalized for COVID-19 have been inconsistent.
Purpose: To estimate the association of higher- versus lower-dose anticoagulation with clinical outcomes.
Data Sources: Randomized trials were identified from the World Health Organization's International Clinical Trials Registry Platform and ClinicalTrials.
Article Synopsis
- Pneumonia, influenza, and COVID-19 can increase the risk of blood clots due to inflammation affecting the thrombotic system, but long-term risks post-hospitalization remain unclear.
- The study analyzed health data from adults in Wales to assess the incidence of arterial and venous thrombosis after hospitalizations due to COVID-19 and compared it with rates after pneumonia or influenza hospitalizations.
- Results indicated heightened risk for arterial thrombosis shortly after COVID-19 hospitalization, with adjusted hazard ratios showing a significant decrease in risk over time, but still elevated compared to individuals without COVID-19 hospitalizations.
Immortal time may arise in survival analyses when individuals are assigned to treatment strategies based on post-eligibility information or selected based on post-assignment eligibility criteria. Selection based on eligibility criteria applied after treatment assignment results in immortal time when the analysis starts the follow-up at assignment. Misclassification of assignment to treatment strategies based on treatment received after eligibility results in immortal time when the treatment strategies are not distinguishable at the start of follow-up.
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