Publications by authors named "J SCHILLER"
Article Synopsis
- The primary motor cortex (M1) is essential for learning motor skills, and dopaminergic signaling from the ventral-tegmental area (VTA) plays a significant role in this process.
- Using techniques like calcium imaging and chemogenetic inhibition, researchers found that learning a dexterity task leads to a reorganization of M1 layer 2-3, changing how neurons connect and communicate while maintaining overall activity levels.
- Blocking VTA signals during learning halted these neural changes, highlighting the importance of dopaminergic input in developing outcome signaling and refined connectivity in M1, which is crucial for acquiring new motor skills.
Background: Herniated discs are a common cause of neurological symptoms that often lead to reduced quality of life. They affect around 20% of 45-56-year olds and, therefore, represent a correspondingly major challenge for healthcare. Conservative therapy methods are usually used as the first treatment option; surgical interventions should only be considered in special symptom constellations.
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- Live-cell imaging of cholesterol trafficking requires suitable fluorescent cholesterol analogs, but current options have significant drawbacks, such as differing properties or requiring UV excitation.
- The study introduces two new fluorescent sterol probes that resemble cholesterol closely, enhancing their applicability for imaging.
- One probe features visible emissions suitable for conventional microscopy, while the other proves unstable and unusable, making the first a better choice for studying sterol transport in live cells.*
Background: The Costa Rica HPV Vaccine Trial provided initial evidence that 1 dose of the bivalent human papillomavirus (HPV) vaccine induces stabilizing antibody levels that may provide extended protection against HPV-16/18 infections. We report antibody seropositivity and stability 11 to 16 years after vaccination.
Methods: We invited a random subset of Costa Rica HPV Vaccine Trial participants (n = 398) who had received 3 doses and all women (n = 203) who had received 1 dose at 18 to 25 years of age to follow-up visits 11, 14, and 16 years after vaccination.
A warming planet will have devasting effects on human health - including the care, diagnosis, prevention, and treatment of cancer patients. As oncology health care professionals, we have a moral and professional obligation to educate our peers, health systems, the public, and other stakeholders as to the dangers they can expect, and how they can be prevented or mitigated. There are numerous ways that we, as trusted messengers, can take action, either personally, locally, nationally, or by supporting non-profit organizations advocating for climate change and cancer.
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